Article
Association study between interleukin-12 receptor beta1/beta2 genes and type 1 diabetes or asthma in the Japanese population.
Immunogenetics - 1 Jun 2003
Bassuny Wafaa M, Ihara Kenji, Kimura Junko, Ichikawa Shigeki, Kuromaru Ryuichi, Miyako Kenichi, Kusuhara Kouichi, Sasaki Yuka, Kohno Hitoshi, Matsuura Nobuo, Nishima Sankei, Hara Toshiro
Abstract excerpt
Interleukin-12 (IL-12) secreted from macrophages or dendritic cells plays an important role in the protection against intracellular pathogens as well as the developmental commitment of T helper 1 cells. IL-12 exerts its biological effects through binding to specific IL-12 receptors (IL-12Rs) termed IL-12Rbeta1 and IL 12Rbeta2. In this paper, we performed association studies between the three reported...
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