Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.

Science (New York, N.Y.) - 9 Sept 2005

Mekel-Bobrov Nitzan, Gilbert Sandra L, Evans Patrick D, Vallender Eric J, Anderson Jeffrey R, Hudson Richard R, Tishkoff Sarah A, Lahn Bruce T

Abstract excerpt

The gene ASPM (abnormal spindle-like microcephaly associated) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong positive selection. Here, we show that one genetic variant of ASPM in humans arose merely about 5800 years ago and has since swept to high frequency under strong positive selection. These findings, especially the remarkably young age of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Biological
Share to Black People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Conversion

Share to Nerve Tissue Proteins

Share to Organ Size

Share to Pan troglodytes

Share to Recombination, Genetic

Source

Identifiers

PMID: 16151010
DOI: 10.1126/science.1116815

Genes

ASPM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.PMID 16151010Read ↗

Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.Semantic proximity Read ↗

Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".Semantic proximity Read ↗

Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.Semantic proximity Read ↗

The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence.Semantic proximity Read ↗

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.Semantic proximity Read ↗

Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates.Semantic proximity Read ↗

Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM.Semantic proximity Read ↗

Normal variants of Microcephalin and ASPM do not account for brain size variability.Semantic proximity Read ↗

Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.Semantic proximity Read ↗

Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution.Semantic proximity Read ↗

Large Phenotypic Variation of Individuals from a Family with a Novel ASPM Mutation Associated with Microcephaly, Epilepsy, and Behavioral and Cognitive Deficits.Semantic proximity Read ↗

A novel splice-site mutation in the ASPM gene underlies autosomal recessive primary microcephaly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.