Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM.

Science (New York, N.Y.) - 24 Aug 2007

Timpson Nicholas, Heron Jon, Smith George Davey, Enard Wolfgang

Abstract excerpt

Evans et al. and Mekel-Bobrov et al. (Reports, 9 September 2005, p. 1717 and 1720, respectively) reported that human genetic variants of Microcephalin (MCPH1) and abnormal spindle-like microcephaly associated (ASPM) are under strong positive selection. We genotyped these variants in 9000 children and find no meaningful associations with brain size and various cognitive measures, which indicates that contrary to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Cell Cycle Proteins
Share to Cephalometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition

Share to Cytoskeletal Proteins

Share to Motor Skills

Share to Nerve Tissue Proteins

Share to Selection, Genetic

Source

Identifiers

PMID: 17717170
DOI: 10.1126/science.1141705

Genes

ASPM
MCPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM.PMID 17717170Read ↗

Normal variants of Microcephalin and ASPM do not account for brain size variability.Semantic proximity Read ↗

Investigation of MCPH1 G37995C and ASPM A44871G polymorphisms and brain size in a healthy cohort.Semantic proximity Read ↗

Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.Semantic proximity Read ↗

A common SNP of MCPH1 is associated with cranial volume variation in Chinese population.Semantic proximity Read ↗

Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".Semantic proximity Read ↗

The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence.Semantic proximity Read ↗

Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings.Semantic proximity Read ↗

Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.Semantic proximity Read ↗

Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates.Semantic proximity Read ↗

Sex-dependent association of common variants of microcephaly genes with brain structure.Semantic proximity Read ↗

Autosomal recessive primary microcephaly due to ASPM mutations: An update.Semantic proximity Read ↗

Low-frequency variation in TP53 has large effects on head circumference and intracranial volumeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.