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Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution.

Human genetics - 1 Feb 2017

Shi Lei, Hu Enzhi, Wang Zhenbo, Liu Jiewei, Li Jin, Li Ming, Chen Hua, Yu Chunshui, Jiang Tianzi, Su Bing

Abstract excerpt

Human evolution is marked by a continued enlargement of the brain. Previous studies on human brain evolution focused on identifying sequence divergences of brain size regulating genes between humans and nonhuman primates. However, the evolutionary pattern of the brain size regulating genes during recent human evolution is largely unknown. We conducted a comprehensive analysis of the brain size regulating gene...

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PMID: 27878434
DOI: 10.1007/s00439-016-1748-5

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