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Article

Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.

Science (New York, N.Y.) - 9 Sept 2005

Evans Patrick D, Gilbert Sandra L, Mekel-Bobrov Nitzan, Vallender Eric J, Anderson Jeffrey R, Vaez-Azizi Leila M, Tishkoff Sarah A, Hudson Richard R, Lahn Bruce T

Abstract excerpt

The gene Microcephalin (MCPH1) regulates brain size and has evolved under strong positive selection in the human evolutionary lineage. We show that one genetic variant of Microcephalin in modern humans, which arose approximately 37,000 years ago, increased in frequency too rapidly to be compatible with neutral drift. This indicates that it has spread under strong positive selection, although the exact nature of...

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Source

Identifiers

PMID: 16151009
DOI: 10.1126/science.1113722

Genes

MCPH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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