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Article

Normal variants of Microcephalin and ASPM do not account for brain size variability.

Human molecular genetics - 15 Jun 2006

Woods Roger P, Freimer Nelson B, De Young Joseph A, Fears Scott C, Sicotte Nancy L, Service Susan K, Valentino Daniel J, Toga Arthur W, Mazziotta John C

Abstract excerpt

Normal human brain volume is heritable. The genes responsible for variation in brain volume are not known. Microcephalin (MCPH1) and ASPM (abnormal spindle-like microcephaly associated) have been proposed as candidate genes as mutations in both genes are associated with microcephaly, and common variants of each gene are apparently under strong positive selective pressure. In 120 normal subjects, we genotyped...

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Source

Identifiers

PMID: 16687438
DOI: 10.1093/hmg/ddl126

Genes

ASPM
MCPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Normal variants of Microcephalin and ASPM do not account for brain size variability.PMID 16687438Read ↗

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The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence.Semantic proximity Read ↗

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Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.Semantic proximity Read ↗

Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.Semantic proximity Read ↗

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