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Article

Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".

Science (New York, N.Y.) - 20 Apr 2007

Yu Fuli, Hill R Sean, Schaffner Stephen F, Sabeti Pardis C, Wang Eric T, Mignault Andre A, Ferland Russell J, Moyzis Robert K, Walsh Christopher A, Reich David

Abstract excerpt

Mekel-Bobrov et al. (Reports, 9 September 2005, p. 1720) suggested that ASPM, a gene associated with microcephaly, underwent natural selection within the last 500 to 14,100 years. Their analyses based on comparison with computer simulations indicated that ASPM had an unusual pattern of variation. However, when we compare ASPM empirically to a large number of other loci, its variation is not unusual and does not...

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Identifiers

PMID: 17446375
DOI: 10.1126/science.316.5823.370a

Genes

ASPM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".PMID 17446375Read ↗

Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.Semantic proximity Read ↗

Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.Semantic proximity Read ↗

The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence.Semantic proximity Read ↗

Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.Semantic proximity Read ↗

Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates.Semantic proximity Read ↗

Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM.Semantic proximity Read ↗

Large Phenotypic Variation of Individuals from a Family with a Novel ASPM Mutation Associated with Microcephaly, Epilepsy, and Behavioral and Cognitive Deficits.Semantic proximity Read ↗

Primary microcephaly: microcephalin and ASPM determine the size of the human brain.Semantic proximity Read ↗

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Molecular evolution of microcephalin, a gene determining human brain size.Semantic proximity Read ↗

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