The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence.

doi:10.1093/hmg/ddl487

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The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence.

Human molecular genetics - 15 Mar 2007

Mekel-Bobrov Nitzan, Posthuma Danielle, Gilbert Sandra L, Lind Penelope, Gosso M Florencia, Luciano Michelle, Harris Sarah E, Bates Timothy C, Polderman Tinca J C, Whalley Lawrence J, Fox Helen, Starr John M, Evans Patrick D, Montgomery Grant W, Fernandes Croydon, Heutink Peter, Martin Nicholas G, Boomsma Dorret I, Deary Ian J, Wright Margaret J, de Geus Eco J C, Lahn Bruce T

Abstract excerpt

Recent studies have made great strides towards identifying putative genetic events underlying the evolution of the human brain and its emergent cognitive capacities. One of the most intriguing findings is the recurrent identification of adaptive evolution in genes associated with primary microcephaly, a developmental disorder characterized by severe reduction in brain size and intelligence, reminiscent of the...

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PMID: 17220170
DOI: 10.1093/hmg/ddl487

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ASPM

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The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence.PMID 17220170Read ↗

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Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates.Semantic proximity Read ↗

Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.Semantic proximity Read ↗

Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.Semantic proximity Read ↗

Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage.Semantic proximity Read ↗

Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.Semantic proximity Read ↗

Microcephaly genes and the evolution of sexual dimorphism in primate brain size.Semantic proximity Read ↗

Normal variants of Microcephalin and ASPM do not account for brain size variability.Semantic proximity Read ↗

Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.Semantic proximity Read ↗

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Molecular evolution of microcephalin, a gene determining human brain size.Semantic proximity Read ↗

A Two-Base Pair Deletion in IQ Repeats in ASPM Underlies Microcephaly in a Pakistani Family.Semantic proximity Read ↗

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