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Article

Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.

Human molecular genetics - 1 Mar 2004

Evans Patrick D, Anderson Jeffrey R, Vallender Eric J, Gilbert Sandra L, Malcom Christine M, Dorus Steve, Lahn Bruce T

Abstract excerpt

A prominent trend in the evolution of humans is the progressive enlargement of the cerebral cortex. The ASPM (Abnormal spindle-like microcephaly associated) gene has the potential to play a role in this evolutionary process, because mutations in this gene cause severe reductions in the cerebral cortical size of affected humans. Here, we show that the evolution of ASPM is significantly accelerated in great apes,...

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Source

Identifiers

PMID: 14722158
DOI: 10.1093/hmg/ddh055

Genes

ASPM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.PMID 14722158Read ↗

Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.Semantic proximity Read ↗

Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.Semantic proximity Read ↗

Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".Semantic proximity Read ↗

The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence.Semantic proximity Read ↗

Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates.Semantic proximity Read ↗

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.Semantic proximity Read ↗

Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution.Semantic proximity Read ↗

Molecular evolution of microcephalin, a gene determining human brain size.Semantic proximity Read ↗

Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage.Semantic proximity Read ↗

Normal variants of Microcephalin and ASPM do not account for brain size variability.Semantic proximity Read ↗

A novel splice-site mutation in the ASPM gene underlies autosomal recessive primary microcephaly.Semantic proximity Read ↗

Insights into brain evolution through the genotype-phenotype connection.Semantic proximity Read ↗

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