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Article

Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.

Human molecular genetics - 1 Mar 2004

Evans Patrick D, Anderson Jeffrey R, Vallender Eric J, Gilbert Sandra L, Malcom Christine M, Dorus Steve, Lahn Bruce T

Abstract excerpt

A prominent trend in the evolution of humans is the progressive enlargement of the cerebral cortex. The ASPM (Abnormal spindle-like microcephaly associated) gene has the potential to play a role in this evolutionary process, because mutations in this gene cause severe reductions in the cerebral c...

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Source

Identifiers

PMID: 14722158
DOI: 10.1093/hmg/ddh055

Genes

ASPM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14722158-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.PMID 14722158Read ↗

Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.Semantic proximity Read ↗

Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.Semantic proximity Read ↗

Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".Semantic proximity Read ↗

The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence.Semantic proximity Read ↗

Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates.Semantic proximity Read ↗

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.Semantic proximity Read ↗

Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution.Semantic proximity Read ↗

Molecular evolution of microcephalin, a gene determining human brain size.Semantic proximity Read ↗

Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage.Semantic proximity Read ↗

Normal variants of Microcephalin and ASPM do not account for brain size variability.Semantic proximity Read ↗

A novel splice-site mutation in the ASPM gene underlies autosomal recessive primary microcephaly.Semantic proximity Read ↗

Insights into brain evolution through the genotype-phenotype connection.Semantic proximity Read ↗

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