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Article

A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling.

Endocrinology - 1 Dec 2005

Claus Maren, Jaeschke Holger, Kleinau Gunnar, Neumann Susanne, Krause Gerd, Paschke Ralf

Abstract excerpt

Previous reports on the follicle-stimulating hormone receptor and choriogonadotropic/LH receptor, which belong to the glycoprotein hormone receptor family, suggest that the extracellular loop (ECL) 3 could be a key domain for ligand binding and intramolecular receptor signaling. In contrast to ECLs 1 and 2 of glycoprotein hormone receptors, the ECL3 displays high sequence homology, particularly in the central...

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Source

Identifiers

PMID: 16150909
DOI: 10.1210/en.2005-0713

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TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling.PMID 16150909Read ↗

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