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Article

Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor.

The Journal of biological chemistry - 5 Jan 2007

Kleinau Gunnar, Claus Maren, Jaeschke Holger, Mueller Sandra, Neumann Susanne, Paschke Ralf, Krause Gerd

Abstract excerpt

A number of alanine mutations in extracellular loop two (ECL2) of the thyroid-stimulating hormone receptor (TSHR) were found to increase or decrease basal activity when compared with the wild type receptor. K565A was identified as a mutant with decreased basal activity, and strongly impaired hormone induced signaling activity. To gain insights into how ECL2 mutants affect basal activity, we focused on...

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Source

Identifiers

PMID: 17079233
DOI: 10.1074/jbc.M606176200

Genes

TSHR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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