Article
The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction.
Molecular endocrinology (Baltimore, Md.) - 1 May 2008
Mizutori Yumiko, Chen Chun-Rong, McLachlan Sandra M, Rapoport Basil
Abstract excerpt
The glycoprotein hormone receptor hinge region connects the leucine-rich and transmembrane domains. The prevalent concept is that the hinge does not play a significant role in ligand binding and signal transduction. Portions of the hinge are redundant and can be deleted by mutagenesis or are absent in certain species. A minimal hinge will be more amenable to future investigation of its structure and function. We,...
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