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Article

Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor.

Endocrinology - 1 Jan 2005

Neumann Susanne, Krause Gerd, Claus Maren, Paschke Ralf

Abstract excerpt

The TSH receptor (TSHR) activates mainly two signal transduction pathways, cAMP production and phosphoinositide turnover, mediated by Gs and Gq coupling, respectively. Several activating deletion and point mutations within intracellular loop 3 (ICL3) and the adjacent portion of transmembrane domain 6 (TM6) support a direct G protein activation by this receptor domain. The ICL3, however, is predicted by modeling...

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Source

Identifiers

PMID: 15498884
DOI: 10.1210/en.2004-1045

Genes

TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor.PMID 15498884Read ↗

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