Article
Thrombospondin-4 and its variants: expression and differential effects on endothelial cells.
Circulation - 23 Sept 2003
Stenina Olga I, Desai Shailesh Y, Krukovets Irene, Kight Kelly, Janigro Damir, Topol Eric J, Plow Edward F
Abstract excerpt
BACKGROUND: In a recent large-scale genetic association study, a single nucleotide polymorphism in the thrombospondin-4 (TSP-4) gene, resulting in a proline-for-alanine substitution at position 387, was associated with a significantly increased risk for premature atherosclerosis. TSP-4 had not previously been implicated in vascular pathology, and very little information is available on its expression and...
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