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Article

Functional domains of the mouse beta3-adrenoceptor associated with differential G protein coupling.

The Journal of pharmacology and experimental therapeutics - 1 Dec 2005

Sato Masaaki, Hutchinson Dana S, Bengtsson Tore, Floren Anders, Langel Ulo, Horinouchi Takahiro, Evans Bronwyn A, Summers Roger J

Abstract excerpt

Alternative splicing of mouse beta3-adrenoceptor transcripts produces an additional receptor isoform (beta3b-adrenoceptor) with a C terminus comprising 17 amino acids distinct from the 13 in the known receptor (beta3a-adrenoceptor). We have shown that the beta3b-adrenoceptor couples to both Gs and Gi, whereas the beta3a-adrenoceptor couples only to Gs. To define the regions involved in this differential G protein...

Read the complete abstract on PubMed

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Share to Adrenergic beta-Antagonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, Gi-Go

Share to GTP-Binding Protein alpha Subunits, Gs

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Share to Receptors, Adrenergic, beta-3

Source

Identifiers

PMID: 16144970
DOI: 10.1124/jpet.105.091736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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