Article
Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.
The Journal of biological chemistry - 18 Nov 2005
de Bouteiller Odette, Merck Estelle, Hasan Uzma A, Hubac Sylvain, Benguigui Barbara, Trinchieri Giorgio, Bates Elizabeth E M, Caux Christophe
Abstract excerpt
Studies involving Toll-like receptor 3 (TLR3)-deficient mice suggest that this receptor binds double-stranded RNA. In the present study, we analyzed ligand/receptor interactions and receptor-proximal events leading to TLR3 activation. The mutagenesis approach showed that certain cysteine residues and glycosylation in TLR3 amino-terminal leucine-rich repeats were necessary for ligand-induced signaling....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.