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Article

Double-stranded RNA signaling by Toll-like receptor 3 requires specific tyrosine residues in its cytoplasmic domain.

The Journal of biological chemistry - 14 Feb 2003

Sarkar Saumendra N, Smith Heather L, Rowe Theresa M, Sen Ganes C

Abstract excerpt

Double-stranded (ds) RNA, a common product of viral infection, can induce transcription of many cellular genes, including the 561 gene that encodes P56, a regulator of protein synthesis. Here, we report that induction of the 561 mRNA by exogenous dsRNA is mediated by Toll-like receptor 3 (TLR3), and it requires no new protein synthesis. Because gene induction by dsRNA is blocked by inhibitors of tyrosine kinases,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Cell Surface

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Source

Identifiers

PMID: 12509442
DOI: 10.1074/jbc.C200655200

Genes

TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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