Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

N-terminal binding site in the human toll-like receptor 3 ectodomain.

Nucleic acids symposium series (2004) - 1 Jan 2007

Watanabe Tomoya, Tokisue Takashi, Tsujita Tadayuki, Matsumoto Misako, Seya Tsukasa, Nishikawa Satoshi, Hasegawa Tsunemi, Fukuda Kotaro

Abstract excerpt

Toll-like receptors (TLRs) are an essential component of the innate immune response to microbial pathogens. TLR3 is localized in intracellular compartments such as endosomes and signals in response to virus-derived dsRNA. The TLR3 ectodomain (ECD), which is implicated in dsRNA recognition, is a horseshoe-shaped solenoid composed of 23 leucine-rich repeats (LRRs). Recent mutagenesis studies on TLR3 ECD revealed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Histidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen-Ion Concentration

Share to Ligands

Share to Mutation

Share to Protein Structure, Tertiary

Share to RNA, Double-Stranded

Share to Toll-Like Receptor 3

Source

Identifiers

PMID: 18029758
DOI: 10.1093/nass/nrm203

Genes

TLR3
ECD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

N-terminal binding site in the human toll-like receptor 3 ectodomain.PMID 18029758Read ↗

The dsRNA binding site of human Toll-like receptor 3.Semantic proximity Read ↗

The toll-like receptor 3:dsRNA signaling complex.Semantic proximity Read ↗

The N-terminal region of IFITM3 modulates its antiviral activity by regulating IFITM3 cellular localization.Semantic proximity Read ↗

Comprehensive modeling and functional analysis of Toll‐like receptor ligand‐recognition domainsSemantic proximity Read ↗

Structural and functional analyses of the human Toll-like receptor 3. Role of glycosylation.Semantic proximity Read ↗

The CDR3 region as the major driver of TREM-1 interaction with its ligands, an in silico characterizationSemantic proximity Read ↗

Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation.Semantic proximity Read ↗

RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi.Semantic proximity Read ↗

Internalization of the host alkaline pH signal in a fungal pathogenSemantic proximity Read ↗

Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling.Semantic proximity Read ↗

Structure of the LDL receptor extracellular domain at endosomal pH.Semantic proximity Read ↗

Role of conserved histidine residues in the low-pH dependence of the Semliki Forest virus fusion protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.