Article
Carboxyl-terminus determinants of the iron transporter DMT1/SLC11A2 isoform II (-IRE/1B) mediate internalization from the plasma membrane into recycling endosomes.
Biochemistry - 13 Sept 2005
Lam-Yuk-Tseung Steven, Touret Nicolas, Grinstein Sergio, Gros Philippe
Abstract excerpt
Mutations in DMT1 (Nramp2 and Slc11a2) impair iron metabolism and cause microcytic anemia. DMT1 is expressed at the duodenal brush border where it controls uptake of dietary iron and is present at the plasma membrane and in recycling endosomes of most cells, where it is necessary for acquisition of transferrin-associated iron. The goal of this study was to identify signal(s) in the cytoplasmic segments of DMT1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.