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Article

C-terminal di-leucine motif of dopamine D₁ receptor plays an important role in its plasma membrane trafficking.

PloS one - 1 Jan 2011

Guo Yan, Jose Pedro A

Abstract excerpt

The dopamine D₁ receptor (D₁R), a G protein-coupled receptor, plays a critical role in regulating blood pressure through its actions on renal hemodynamics and epithelial ion transport, which are highly linked to its intracellular trafficking. In this study, we generated a series of C-terminal mutants of D₁R that were tagged with or without enhanced yellow fluorescent protein, and analyzed the consequences of...

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Share to Amino Acid Motifs
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22206002
DOI: 10.1371/journal.pone.0029204
PMCID: PMC3242775

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