Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The dynamics of hepcidin-ferroportin internalization and consequences of a novel ferroportin disease mutation.

American journal of hematology - 1 Oct 2017

Wallace Daniel F, McDonald Cameron J, Ostini Lesa, Iser David, Tuckfield Annabel, Subramaniam V Nathan

Abstract excerpt

The hepcidin-ferroportin axis underlies the pathophysiology of many iron-associated disorders and is a key target for the development of therapeutics for treating iron-associated disorders. The aims of this study were to investigate the dynamics of hepcidin-mediated ferroportin internalization and the consequences of a novel disease-causing mutation on ferroportin function. Specific reagents for ferroportin are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Assay
Share to Cation Transport Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ferroportin

Share to Hepcidins

Share to Iron Metabolism Disorders

Share to Protein Transport

Share to Receptors, Cell Surface

Source

Identifiers

PMID: 28681497
DOI: 10.1002/ajh.24844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The dynamics of hepcidin-ferroportin internalization and consequences of a novel ferroportin disease mutation.PMID 28681497Read ↗

Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin.Semantic proximity Read ↗

Twenty Years of Ferroportin Disease: A Review or An Update of Published Clinical, Biochemical, Molecular, and Functional FeaturesSemantic proximity Read ↗

Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype.Semantic proximity Read ↗

The dual loss and gain of function of the FPN1 iron exporter results in the ferroportin disease phenotype.Semantic proximity Read ↗

Hepcidin and Ferroportin: The New Players in Iron MetabolismSemantic proximity Read ↗

The molecular mechanism of hepcidin-mediated ferroportin down-regulation.Semantic proximity Read ↗

The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study.Semantic proximity Read ↗

Clinical presentation and molecular pathophysiology of autosomal dominant hemochromatosis caused by a novel ferroportin mutation.Semantic proximity Read ↗

The Spectra of Disease-Causing Mutations in the Ferroportin 1 (SLC40A1) Encoding Gene and Related Iron Overload Phenotypes (Hemochromatosis Type 4 and Ferroportin Disease)Semantic proximity Read ↗

Impact of D181V and A69T on the function of ferroportin as an iron export pump and hepcidin receptor.Semantic proximity Read ↗

Iron homeostasis: transport, metabolism, and regulation.Semantic proximity Read ↗

Comprehensive functional annotation of 18 missense mutations found in suspected hemochromatosis type 4 patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.