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Article

Gene expression patterns associated with p53 status in breast cancer

1 Dec 2006

Abstract excerpt

BACKGROUND: Breast cancer subtypes identified in genomic studies have different underlying genetic defects. Mutations in the tumor suppressor p53 occur more frequently in estrogen receptor (ER) negative, basal-like and HER2-amplified tumors than in luminal, ER positive tumors. Thus, because p53 mutation status is tightly linked to other characteristics of prognostic importance, it is difficult to identify p53's...

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PMID: 17150101
DOI: 10.1186/1471-2407-6-276

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