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Article

Distinct p53 gene signatures are needed to predict prognosis and response to chemotherapy in ER-positive and ER-negative breast cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2011

Coutant Charles, Rouzier Roman, Qi Yuan, Lehmann-Che Jacqueline, Bianchini Giampaolo, Iwamoto Takayuki, Hortobagyi Gabriel N, Symmans W Fraser, Uzan Serge, Andre Fabrice, de Thé Hugues, Pusztai Lajos

Abstract excerpt

PURPOSE: Estrogen receptor-positive (ER+) and -negative (ER) breast cancers are molecularly distinct diseases. We hypothesized that p53 mutations may lead to different transcriptional changes and carry different prognostic value in these two different types of cancers. EXPERIMENTAL DESIGN: We developed a 39-gene p53 signature derived from 213 ER+ and a separate 30-gene signature from 38 ER- cancers with known...

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PMID: 21248301
DOI: 10.1158/1078-0432.CCR-10-1045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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