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Article

Chromatin assembly factor I mutants defective for PCNA binding require Asf1/Hir proteins for silencing.

Molecular and cellular biology - 1 Jan 2002

Krawitz Denise C, Kama Tamar, Kaufman Paul D

Abstract excerpt

Chromatin assembly factor I (CAF-I) is a conserved histone H3/H4 deposition complex. Saccharomyces cerevisiae mutants lacking CAF-I subunit genes (CAC1 to CAC3) display reduced heterochromatic gene silencing. In a screen for silencing-impaired cac1 alleles, we isolated a mutation that reduced binding to the Cac3p subunit and another that impaired binding to the DNA replication protein PCNA. Surprisingly,...

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Source

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Identifiers

PMID: 11756556
DOI: 10.1128/MCB.22.2.614-625.2002
PMCID: PMC139734

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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