Article
Using tree-based recursive partitioning methods to group haplotypes for increased power in association studies.
Annals of human genetics - 1 Sept 2005
Yu Kai, Xu Jun, Rao D C, Province Michael
Abstract excerpt
Motivated by the increasing availability of high-density single nucleotide polymorphism (SNP) markers across the genome, various haplotype-based methods have been developed for candidate gene association studies, and even for genome-wide association studies. Although haplotype approaches dramatically reduce the multiple comparisons problem (as compared to single SNP analysis), even the number of existing...
Topics
- Algorithms
- Computer Simulation
- Genetic Predisposition to Disease
- Genetics, Population
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Models, Statistical
- Multigene Family