Article
Association mapping by generalized linear regression with density-based haplotype clustering.
Genetic epidemiology - 1 Jan 2009
Igo Robert P, Li Jing, Goddard Katrina A B
Abstract excerpt
Haplotypes of closely linked single-nucleotide polymorphisms (SNPs) potentially offer greater power than individual SNPs to detect association between genetic variants and disease. We present a novel approach for association mapping in which density-based clustering of haplotypes reduces the dimensionality of the general linear model (GLM)-based score test of association implemented in the HaploStats software...
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