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Article

Accelerating haplotype-based genome-wide association study using perfect phylogeny and phase-known reference data.

PloS one - 1 Jan 2011

He Yungang, Li Cong, Amos Christopher I, Xiong Momiao, Ling Hua, Jin Li

Abstract excerpt

The genome-wide association study (GWAS) has become a routine approach for mapping disease risk loci with the advent of large-scale genotyping technologies. Multi-allelic haplotype markers can provide superior power compared with single-SNP markers in mapping disease loci. However, the application of haplotype-based analysis to GWAS is usually bottlenecked by prohibitive time cost for haplotype inference, also...

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Identifiers

PMID: 21789217
DOI: 10.1371/journal.pone.0022097
PMCID: PMC3137625

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