Haplotype block structure and its applications to association studies: power and study designs.

doi:10.1086/344780

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Article

Haplotype block structure and its applications to association studies: power and study designs.

American journal of human genetics - 1 Dec 2002

Zhang Kui, Calabrese Peter, Nordborg Magnus, Sun Fengzhu

Abstract excerpt

Recent studies have shown that the human genome has a haplotype block structure, such that it can be divided into discrete blocks of limited haplotype diversity. In each block, a small fraction of single-nucleotide polymorphisms (SNPs), referred to as "tag SNPs," can be used to distinguish a larg...

Topics

Algorithms
Case-Control Studies
Chromosome Mapping
Computer Simulation
Genetic Markers
Haplotypes
Humans
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Recombination, Genetic
Research Design

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