Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering.

doi:10.1086/521987

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Article

Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering.

American journal of human genetics - 1 Nov 2007

Browning Sharon R, Browning Brian L

Abstract excerpt

Whole-genome association studies present many new statistical and computational challenges due to the large quantity of data obtained. One of these challenges is haplotype inference; methods for haplotype inference designed for small data sets from candidate-gene studies do not scale well to the...

Topics

Algorithms
Alleles
Cluster Analysis
Computational Biology
Genetic Markers
Genetic Predisposition to Disease
Genome, Human
Haplotypes
Humans
Models, Genetic
Time Factors

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