Article
Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines.
Development (Cambridge, England) - 15 May 2026
Guertin Taylor M, Sisson Chip, Gargiulo Rossella M, Macrorie Olivia, Pease Emily L, Garth Hannah E, Vriens Joris, De Clercq Katrien, Mager Jesse, Tremblay Kimberly D
Abstract excerpt
The focus on assessing embryo-specific defects in lethal knockout (KO) mouse lines has resulted in an underrepresentation of documented placental abnormalities. Presented herein is a uniform analysis of 22 distinct KO mouse lines that exhibit homozygous lethality in a narrow mid-gestation window. All genes altered by each KO have human orthologs, most are implicated in human disease, yet almost all are...
Topics
- Animals
- Female
- Pregnancy
- Placenta
- Mice
- Mice, Knockout
- Embryo, Mammalian
- Phenotype
- Gene Expression Regulation, Developmental
- Humans
- Genes, Lethal