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Article

Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.

Molecular and cellular biology - 1 Dec 2010

Rousseau Justine, Klinger Sonia, Rachalski Adeline, Turgeon Benjamin, Déléris Paul, Vigneault Erika, Poirier-Héon Jean-François, Davoli Maria Antonietta, Mechawar Naguib, El Mestikawy Salah, Cermakian Nicolas, Meloche Sylvain

Abstract excerpt

Erk4 and Erk3 are atypical members of the mitogen-activated protein (MAP) kinase family. The high sequence identity of Erk4 and Erk3 proteins and the similar organization of their genes imply that the two protein kinases are paralogs. Recently, we have shown that Erk3 function is essential for neonatal survival and critical for the establishment of fetal growth potential and pulmonary function. To investigate the...

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Identifiers

PMID: 20956558
DOI: 10.1128/MCB.01147-10
PMCID: PMC3004264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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