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Article

Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling.

Molecular and cellular biology - 1 Sept 2005

Kfir Shiri, Ehrlich Marcelo, Goldshmid Ayelet, Liu Xuedong, Kloog Yoel, Henis Yoav I

Abstract excerpt

Overactivation of Ras pathways contributes to oncogenesis and metastasis of epithelial cells in several ways, including interference with cell cycle regulation via the CDK inhibitor p27(Kip1) (p27) and disruption of transforming growth factor beta (TGF-beta) anti-proliferative activity. Here, we show that at high expression levels, constitutively active N-Ras induces cytoplasmic mislocalization of murine and...

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Source

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Identifiers

PMID: 16135812
DOI: 10.1128/MCB.25.18.8239-8250.2005
PMCID: PMC1234306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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