Article
ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF.
Molecular and cellular biology - 1 Sept 2005
Datta Abhishek, Sen Jayita, Hagen Jussara, Korgaonkar Chandrashekhar K, Caffrey Michael, Quelle Dawn E, Hughes Douglas E, Ackerson Timothy J, Costa Robert H, Raychaudhuri Pradip
Abstract excerpt
The tumor suppressor ARF inhibits cell growth in response to oncogenic stress in a p53-dependent manner. Also, there is an increasing appreciation of ARF's ability to inhibit cell growth via multiple p53-independent mechanisms, including its ability to regulate the E2F pathway. We have investigat...
Topics
- Animals
- Cell Cycle Proteins
- Cyclin A
- Cyclin-Dependent Kinase Inhibitor p16
- DNA-Binding Proteins
- Down-Regulation
- E2F Transcription Factors
- E2F1 Transcription Factor
- G1 Phase
- Gene Expression Regulation
- Humans
- Mice
- Mutation
- Promoter Regions, Genetic