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Article

Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasis.

American journal of medical genetics - 8 Jul 2002

Norton Nadine, Kirov George, Zammit Stan, Jones Gaynor, Jones Susan, Owen Richard, Krawczak Michael, Williams Nigel M, O'Donovan Michael C, Owen Michael J

Abstract excerpt

Several lines of evidence suggest that psychosis is associated with altered dopaminergic neurotransmission. Dopamine is catabolized by monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT). We hypothesized that the genes encoding MAOA and COMT might contain genetic variation conferring increased risk to schizophrenia. In order to test this hypothesis, we genotyped the 941T > G and the promoter VNTR...

Read the complete abstract on PubMed

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Share to Catechol O-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Restriction Fragment Length

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Source

Identifiers

PMID: 12116182
DOI: 10.1002/ajmg.10517

Genes

COMT
MAOA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasis.PMID 12116182Read ↗

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