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Article

Gene amplification as a prognostic factor in primary and secondary high-grade malignant gliomas.

1 Oct 1998

Abstract excerpt

The purpose of this study was to examine the incidence of gene amplification in patients with primary (de novo) and secondary high-grade gliomas (gliomas evolving from lower grade malignancies) and to assess its prognostic significance. A total of 186 prospectively collected frozen surgical specimens were analyzed. Extracted DNA was examined by Southern blot using probes corresponding to the EGFR, CDK4, MDM2,...

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Identifiers

PMID: 9735401
DOI: 10.3892/ijo.13.4.717

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Source receipt: pubmed, retrieved 7 Sept 2026.

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