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Article

Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomas.

British journal of cancer - 11 Jul 2005

Bäcklund L M, Nilsson B R, Liu L, Ichimura K, Collins V P

Abstract excerpt

Anaplastic astrocytoma (AA, WHO grade III) is, second to Glioblastoma, the most common and most malignant type of adult CNS tumour. Since survival for patients with AA varies markedly and there are no known useful prognostic or therapy response indicators, the primary purpose of this study was to examine whether knowledge of the known genetic abnormalities found in AA had any clinical value. The survival data on...

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Source

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Identifiers

PMID: 15970925
DOI: 10.1038/sj.bjc.6602661
PMCID: PMC2361485

Genes

CDK4
EGFR
MDM2
PTEN

Provenance

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