Insights into the role of deiodinases from studies of genetically modified animals.

Abstract excerpt

The deiodinases function at a pre-receptor level in tissues to modulate the concentrations, and thus the actions, of thyroid hormones. Although much has been learned in the last two decades about the biochemical properties and expression patterns of these enzymes, a complete understanding of their physiologic roles requires study of their actions in the intact animal. To date only a limited number of naturally...

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