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Article

Essential mechanisms in the catalysis of peptide bond formation on the ribosome.

The Journal of biological chemistry - 28 Oct 2005

Beringer Malte, Bruell Christian, Xiong Liqun, Pfister Peter, Bieling Peter, Katunin Vladimir I, Mankin Alexander S, Böttger Erik C, Rodnina Marina V

Abstract excerpt

Peptide bond formation is the main catalytic function of the ribosome. The mechanism of catalysis is presumed to be highly conserved in all organisms. We tested the conservation by comparing mechanistic features of the peptidyl transfer reaction on ribosomes from Escherichia coli and the Gram-positive bacterium Mycobacterium smegmatis. In both cases, the major contribution to catalysis was the lowering of the...

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Identifiers

PMID: 16129670
DOI: 10.1074/jbc.M507961200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Essential mechanisms in the catalysis of peptide bond formation on the ribosome.PMID 16129670Read ↗

Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome.Semantic proximity Read ↗

The A2453-C2499 wobble base pair in Escherichia coli 23S ribosomal RNA is responsible for pH sensitivity of the peptidyltransferase active site conformation.Semantic proximity Read ↗

The G2447A mutation does not affect ionization of a ribosomal group taking part in peptide bond formation.Semantic proximity Read ↗

Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide.Semantic proximity Read ↗

Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451.Semantic proximity Read ↗

The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity.Semantic proximity Read ↗

Role of ribosomal protein L27 in peptidyl transfer.Semantic proximity Read ↗

The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release.Semantic proximity Read ↗

A single adenosine with a neutral pKa in the ribosomal peptidyl transferase center.Semantic proximity Read ↗

Mutations at the accommodation gate of the ribosome impair RF2-dependent translation termination.Semantic proximity Read ↗

Dissociation rates of peptidyl-tRNA from the P-site of E.coli ribosomes.Semantic proximity Read ↗

Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit.Semantic proximity Read ↗

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