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Article

The G2447A mutation does not affect ionization of a ribosomal group taking part in peptide bond formation.

RNA (New York, N.Y.) - 1 Aug 2003

Beringer Malte, Adio Sarah, Wintermeyer Wolfgang, Rodnina Marina

Abstract excerpt

Peptide bond formation on the ribosome is catalyzed by RNA. Kinetic studies using Escherichia coli ribosomes have shown that catalysis (>10(5)-fold overall acceleration) is due to a large part to substrate positioning. However, peptide bond formation is inhibited approximately 100-fold by protonation of a ribosomal group with pKa=7.5, indicating either a contribution of general acid-base catalysis or inhibition...

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Identifiers

PMID: 12869702
DOI: 10.1261/rna.5600503
PMCID: PMC1370457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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