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Article

FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway.

The Journal of biological chemistry - 28 Oct 2005

Gordon Susan M, Alon Noa, Buchwald Manuel

Abstract excerpt

Fanconi anemia (FA) is a genetically heterogeneous disorder characterized by bone marrow failure, cancer predisposition, and increased cellular sensitivity to DNA-cross-linking agents. The products of seven of the nine identified FA genes participate in a protein complex required for monoubiquitination of the FANCD2 protein. Direct interaction of the FANCE protein with both fellow FA complex component FANCC and...

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Source

Identifiers

PMID: 16127171
DOI: 10.1074/jbc.M507758200

Genes

FANCE
FANCD2
FANCC
FANCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway.PMID 16127171Read ↗

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A novel diagnostic screen for defects in the Fanconi anemia pathwaySemantic proximity Read ↗

Current knowledge on the pathophysiology of Fanconi anemia: from genes to phenotypes.Semantic proximity Read ↗

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.Semantic proximity Read ↗

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