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Article

embB306 mutations as molecular indicators to predict ethambutol susceptibility in Mycobacterium tuberculosis.

Chemotherapy - 1 Jan 2012

Sirgel Frederick A, Warren Robin M, Streicher Elizabeth M, Victor Thomas C, van Helden Paul D, Böttger Erik C

Abstract excerpt

BACKGROUND: Discordant results in conventional susceptibility testing of ethambutol against Mycobacterium tuberculosis may lead to underreporting of drug resistance. METHODS: A 240-bp region of the embB gene in 111 clinical isolates of M. tuberculosis was sequenced and examined for mutations linked to ethambutol resistance. The phenotypic susceptibility levels of the isolates were quantified by the BACTEC™ MGIT...

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Identifiers

PMID: 23171739
DOI: 10.1159/000343474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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