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Article

Evolutionary fingerprinting of genes.

Molecular biology and evolution - 1 Mar 2010

Pond Sergei L Kosakovsky, Scheffler Konrad, Gravenor Michael B, Poon Art F Y, Frost Simon D W

Abstract excerpt

Over time, natural selection molds every gene into a unique mosaic of sites evolving rapidly or resisting change-an "evolutionary fingerprint" of the gene. Aspects of this evolutionary fingerprint, such as the site-specific ratio of nonsynonymous to synonymous substitution rates (dN/dS), are commonly used to identify genetic features of potential biological interest; however, no framework exists for comparing...

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Identifiers

PMID: 19864470
DOI: 10.1093/molbev/msp260
PMCID: PMC2877558

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