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Article

Comparative population genomics: power and principles for the inference of functionality.

Trends in genetics : TIG - 1 Apr 2014

Lawrie David S, Petrov Dmitri A

Abstract excerpt

The availability of sequenced genomes from multiple related organisms allows the detection and localization of functional genomic elements based on the idea that such elements evolve more slowly than neutral sequences. Although such comparative genomics methods have proven useful in discovering functional elements and ascertaining levels of functional constraint in the genome as a whole, here we outline...

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Identifiers

PMID: 24656563
DOI: 10.1016/j.tig.2014.02.002
PMCID: PMC4073783

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Source receipt: pubmed, retrieved 7 Sept 2026.

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