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Article

Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine action.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2006

Zachariou Venetia, Sgambato-Faure Véronique, Sasaki Teresa, Svenningsson Per, Berton Olivier, Fienberg Allen A, Nairn Angus C, Greengard Paul, Nestler Eric J

Abstract excerpt

Mice lacking DARPP-32, a striatal-enriched phosphoprotein, show abnormal behavioral and biochemical responses to cocaine, but the role of individual phosphorylation sites in DARPP-32 in these responses is unknown. We show here that mutation of Thr-34 in DARPP-32 mimicked the behavioral phenotype...

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Identifiers

PMID: 16123776
DOI: 10.1038/sj.npp.1300832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16123776-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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