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Article

DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons.

Nature communications - 7 Dec 2015

Engmann Olivia, Giralt Albert, Gervasi Nicolas, Marion-Poll Lucile, Gasmi Laila, Filhol Odile, Picciotto Marina R, Gilligan Diana, Greengard Paul, Nairn Angus C, Hervé Denis, Girault Jean-Antoine

Abstract excerpt

Environmental enrichment has multiple effects on behaviour, including modification of responses to psychostimulant drugs mediated by striatal neurons. However, the underlying molecular and cellular mechanisms are not known. Here we show that DARPP-32, a hub signalling protein in striatal neurons, interacts with adducins, which are cytoskeletal proteins that cap actin filaments' fast-growing ends and regulate...

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PMID: 26639316
DOI: 10.1038/ncomms10099
PMCID: PMC4675091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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