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Article

MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Mar 2014

Deng Jie V, Wan Yehong, Wang Xiaoting, Cohen Sonia, Wetsel William C, Greenberg Michael E, Kenny Paul J, Calakos Nicole, West Anne E

Abstract excerpt

The methyl-DNA binding protein MeCP2 is emerging as an important regulator of drug reinforcement processes. Psychostimulants induce phosphorylation of MeCP2 at Ser421; however, the functional significance of this posttranslational modification for addictive-like behaviors was unknown. Here we sho...

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Identifiers

PMID: 24671997
DOI: 10.1523/JNEUROSCI.2821-13.2014
PMCID: PMC3965780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24671997-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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