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Article

Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity.

Diabetes - 1 Sept 2005

Feng Ningping, Young Sharla F, Aguilera Greti, Puricelli Elena, Adler-Wailes Diane C, Sebring Nancy G, Yanovski Jack A

Abstract excerpt

Both human linkage studies and MC3R knockout mouse models suggest that the MC3R may play an important role in energy homeostasis. Here we show that among 355 overweight and nonoverweight children, 8.2% were double homozygous for a pair of missense MC3R sequence variants (Thr6Lys and Val81Ile). Such children were significantly heavier (BMI and BMI SD score: P < 0.0001), had more body fat (body fat mass and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16123355
DOI: 10.2337/diabetes.54.9.2663
PMCID: PMC1861848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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