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Article

Prevalence of rare MC3R variants in obese cases and lean controls.

Endocrine - 1 Oct 2013

Zegers Doreen, Beckers Sigri, Hendrickx Rik, Van Camp Jasmijn K, Van Hoorenbeeck Kim, Desager Kristine N, Massa Guy, Van Gaal Luc F, Van Hul Wim

Abstract excerpt

The role of mutations in the melanocortin-3 receptor (MC3R) gene, which is implicated in the regulation of energy homeostasis, is still under debate. Animal studies have clearly proven that, together with the melanocortin-4 receptor (MC4R), the MC3R is a critical receptor for melanocortin peptides within the leptin-melanocortin signaling cascade. However, as several mutations have been found in lean individuals...

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PMID: 23264184
DOI: 10.1007/s12020-012-9862-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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