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Article

Functional characterization of nine novel naturally occurring human melanocortin-3 receptor mutations.

Biochimica et biophysica acta - 1 Nov 2012

Yang Fan, Tao Ya-Xiong

Abstract excerpt

The melanocortin-3 receptor (MC3R) is a member of family A rhodopsin-like G protein-coupled receptors. Mouse genetic studies suggested that MC3R and the related MC4R are non-redundant regulators of energy homeostasis. Lack of Mc3r leads to higher feed efficiency and fat mass. However, until now only a few MC3R mutations have been identified in humans and the role of MC3R in the pathogenesis of obesity was...

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Identifiers

PMID: 22884546
DOI: 10.1016/j.bbadis.2012.07.017
PMCID: PMC3465685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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