Article
Sporadic mutations in melanocortin receptor 3 in morbid obese individuals.
European journal of human genetics : EJHG - 1 May 2008
Mencarelli Monica, Walker Gillian E, Maestrini Sabrina, Alberti Luisella, Verti Barbara, Brunani Amelia, Petroni Maria Letizia, Tagliaferri Mariantonella, Liuzzi Antonio, Di Blasio Anna Maria
Abstract excerpt
Several mutations in the melanocortin receptor 4 gene have been identified in humans and account for 3-6% of morbid obesity. In contrast, strong evidence of a causative role for melanocortin receptor 3 (MC3R) mutations are still lacking. In MC3R knockout mice, high feed efficiency rather than hyperphagia seems to contribute to increased fat mass. On the basis of this evidence, the objective of the present study...
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